Multiscale-galactose metabolism

Multiscale model of human galactose metabolism - from single hepatocytes to individual liver function.

Model overview

Multiscale Galactose Model

GEC App

Calculation of individual liver function based on Galactose Elimination Capacity (GEC).

GEC calculation App GEC App

Cytoscape app for visualizing kinetic data from SABIO-RK

König M.
cy3sabiork: A Cytoscape app for visualizing kinetic data from SABIO-RK
[version 1; referees: awaiting peer review]. F1000Research 2016, 5:1736 (doi: 10.12688/f1000research.9211.1)

cy3sabiork workflow

Tellurium

Choi K., Medley JK., Cannistra C., König M., Smith L., Stocking K., and Sauro HM.
Tellurium: A Python Based Integrated Environment for Biological Modeling and Simulation
bioRxiv 054601; doi: http://dx.doi.org/10.1101/054601 [in revision]

Example simulations

tellurium simulation tellurium simulation

Pathobiochemical signatures of cholestatic liver disease

Kerstin A.*, König M.*, Hoppe A., Thomas M., Müller I., Ebert M., Weng H., Holzhütter HG., Zanger UM., Bode J., Vollmar B. and Dooley S.
* equal contribution
Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice
BMC Syst Biol. 2015 Nov 20;9(1):83. doi: 10.1186/s12918-015-0229-0 [PubMed]

BDL correlation heatmap